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مقاس:30 عد

1 Introduction Mucosal tissues serve as critical frontline barriers, continually exposed to a wide array of infectious pathogens ( It is now well established that a distinct subset of non-recirculating tissue-resident memory T cells (T RM ) arises and persists within peripheral non-lymphoid mucosal tissues ( RM cells are phenotypically and functionally distinct from conventional circulating memory T cells, including effector memory (T EM ) and central memory (T CM ) subsets, which transit through the bloodstream and secondary lymphoid and non-lymphoid tissues ( + and CD8 + T RM cells within mucosal tissues are mechanistically distinct from those that guide conventional T EM and TCM populations ( Current paradigms suggest that the tissue-specific trafficking of memory and effector CD4 + and CD8 + T cells to mucosal sites is governed by the coordinated expression of adhesion molecules and epithelial-derived chemokines, often in a tissue-restricted manner ( Table 1 )